PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice
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چکیده
منابع مشابه
Regulation of branched-chain amino acid catabolism.
Catabolism of the branched-chain amino acids is regulated in part at the step catalyzed by the branched-chain alpha-ketoacid dehydrogenase complex. Previous work suggests both short-term and long-term control mechanisms are involved in regulation of the kinase responsible for phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex. Recent work of this laborat...
متن کاملPGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle
Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors, which is involved in the regulation of energy metabolism, thermogenesis, and other biological processes that control phenotypic characteristics of various organ systems including skeletal muscle. PGC-1α in skeletal muscle is considered to be ...
متن کاملDoctorial Thesis Regulation of Branched-Chain Amino Acid Catabolism
........................................................................................................... 1 Abbreviations ................................................................................................... 3 Chapter 1 General introduction ........................................................................ 3 1. The importance of branched chain amino acids ....................
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The kinetics of transamination reactions catalyzed by pig heart “branched chain amino acid” aminotransferase was investigated. The activation of aged preparations by 2mercaptoethanol, previously noted, was associated with increases in both the maximum velocity and enzyme-substrate affinities. This implies a protein conformational change. The sharp pH optimum observed with standard assay conditi...
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PURPOSE OF REVIEW The current review aims to provide an update on the recent biomedical interest in oncogenic branched-chain amino acid (BCAA) metabolism, and discusses the advantages of using BCAAs and expression of BCAA-related enzymes in the treatment and diagnosis of cancers. RECENT FINDINGS An accumulating body of evidence demonstrates that BCAAs are essential nutrients for cancer growth...
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ژورنال
عنوان ژورنال: Nutrition & Metabolism
سال: 2018
ISSN: 1743-7075
DOI: 10.1186/s12986-018-0298-3